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  • Derivatives of three plant sterols reduce body fat 50-90% in mice

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    Sunday, January 09, 2005 9:14 am Email this article
    Derivatives of three plant sterols--beta-sitosterol, campesterol and stigmasterol--reduced weight gain and body fat as well as cholesterol and triglycerides in young mice according to a study from researchers at the Japan Science and Technology Corporation in Japan. Four plant sterol derivatives reduce fat by 50-90%

    Four of the phytosterol derivatives reduced body fat by 50 to 90 percent compared to the control animals or those that were given the plant sterols themselves.

    No toxicity

    The animals showed no signs of toxicity either when examined while alive or upon autopsy.

    “Remarkably safe” because poorly absorbed

    Sadly the authors of the study did not say what the mechanism of action was, but they noted that plant sterols seem “remarkably safe since [they are difficult] to absorb from the intestines.”

    Hopefully we will see a follow-up to this study using larger animals.

    Note: The compounds were derivatives of plant sterols, not the plant sterols themselves

    Note that these were derivatives of beta-sitosterol and other plant sterols, not beta sitosterol itself.

    Beta sitosterol is sold as a supplement and may be effective for lowering cholesterol, however, this is not the compound used in the study which caused fat loss.


    Suzuki K; Shimizu T; Nakata T. Lowering effect of phytostenones on serum lipid and body fat accumulation in mice. International Journal of Obesity, May 2000, 24 (Suppl 1), S175 (abstract 596).”

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