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Glucose and fructose are very different, only the liver can metabolize fructose, Robert Lustig, MD
Wednesday, June 06, 2012 11:58 am Email this article
"Glucose and fructose are very different, " notes Robert Lustig, MD, pediatric endocrinoligist from the University of California, San Francisco in a 7-part video series called "The Skinny on Obesity" (Episode 2).
He notes that every organism on the planet can absorb and metabolize glucose, but only the liver can metabolize fructose, which, when we consume too much fructose, overloads the liver and causes numerous chronic diseases.
Glucose metabolized by all organs
Glucose metabolized by all organs in the body
“Glucose is metabolized by all the organs of the body.
“Every single living organism on the planet can digest, absorb and metabolize glucose.
“Glucose is the energy of life.
“If you don’t have glucose in your diet, your body makes it because your cells run on it.
80% of glucose metabolized by all organs
80% of glucose metabolized by all organs; 20% goes to the liver
“And 80% of the carbohydrate, glucose, that you consume is metabolized by all the organs of the body.
“Only 20% [of glucose] goes to the liver.
Fructose can only be metabolized by the liver
Eating too much fructose overloads the liver
“Fructose, on the other hand, is not glucose.
“Fructose can only be metabolized in the liver, because only the liver has the transporter for fructose.
“All of the fructose goes to the liver.
“So [when you eat too much fructose] you are overloading the liver. That’s the rub.
Too much fructose causes mitochondrial problems
Too much fructose causes mitochondrial problems, and you get sick
“Fructose goes straight to the mitochondria, and is turned into fat. A little bit of glucose goes to glycogen [the storage form of glucose in the body] until it is replete [the storage bins are full], and then it goes to fat.
“And you have a recipe for mitochondrial meltdown. Mitochondrial constipation. Mitochondrial disease.
“And when you have mitochondrial disease, you get sick.”
Robert Lustig, MD. The The Skinny on Obesity, Episode 2.
UCTV Prime: The Skinny on Obesity
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