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Hypoglycemia increases risk of CAD death by 30% over 8 years in patients with CAD
Tuesday, June 28, 2011 12:21 pm Email this article
Hypoglycemia, defined as having a blood sugar level of 69 mg/dl or less, increased the risk of dying from cancer by 30 percent during the next eight years in patients with coronary artery disease (CAD) compared to those with normal blood sugar levels of 80-109 mg/dl according to a 2004 study.
The difference did not reach statistical significance, meaning there was greater than a 5% chance the difference was due to random chance, however, it still suggests that it is likely. Subjects
Subjects: 14,670 patients, 45-74 years-old
The study included 14,670 patients, 45- to 74-years-old, with coronary artery disease.
131 with hypoglycaemia (0.9%),
731 with low normal glucose (5%),
9308 euglycaemic (63.4%),
1577 with IFG (10.7%),
617 borderline diabetics (4.2%) and
2306 diabetics (15.7%),” the paper noted.
Conclusion: Hypoglycemia increases the risk of death in those with coronary artery disease
“Over a mean 8-year follow-up, hypoglycaemia emerges as a marker for substantially increased all-cause and cancer mortality among patients with [coronary artery disease] presenting with low fasting glucose levels,” the authors of the paper concluded.
“Actuarial survival curves showed the lowest mortality in euglycaemic [those with normal blood sugar levels of 80-109 mg/dl] and low normal groups [70-79 mg/dl]; the highest was seen in diabetic [140 mg/dl or greater] and hypoglycaemic patients [69 mg/dl or less].”
Fisman E, Motro M, Tenenbaum A, Leor J, Boyko V, Mandelzweig L, Sherer Y, Adler Y, Behar S. Is hypoglycaemia a marker for increased long-term mortality risk in patients with coronary artery disease? An 8-year follow-up. Eur J Cardiovasc Prev Rehabil. 2004 Apr, 11(2):135-43.
AUTHOR’S CONTACT INFORMATION
Cardiac Rehabilitation Institute
Chaim Medical Center
Tel-Hashomer, and Sackler Faculty of Medicine
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