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Low dose Qnexa: 7.5 mg Phentermine plus 46 mg Topamax causes weight loss of 8.5% vs 1.7% w/ placebo
Thursday, December 11, 2008 6:58 am Email this article
A half dose of Qnexa, which is 7.5 mg of phentermine plus 46 mg of Topamax (topiramate), caused an average weight loss of 18.2 pounds versus 3.3 pounds with placebo, or 8.5 percent versus 1.7 percent during a six month study according to a press release from press release from Vivus, Inc, the company developing the drug. Duration
Duration: One month of increasing the dose plus six months
The study gradually increased the dose over one month (4 weeks) followed by an additional six months.
Subjects: 756 people
The study, called The EQUATE study, “included 756 obese subjects (599 females and 157 males) across 32 centers in the United States.”
Starting weight: 223 lbs, BMI of 36
Patients started the study at an average of 223 pounds with a body mass index (BMI) of 36.3.
Vivus. Qnexa meets primary endpoint by demonstrating superior weight loss over components and placebo in the 28-week equate study (ob-301) : Subjects on full-dose qnexa attained an average weight loss of 9.2% with 66% achieving 5% or greater weight loss. Press Release from Vivus Inc. 2008 Dec 11, http://ir.vivus.com/phoenix.zhtml?c=79161&p=irol-newsArticle&ID=1235079&highlight=
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