Medium-intensity statin therapy combined with a diuretic increases risk of acute kidney injury 23%

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Friday, April 05, 2019 10:25 am Email this article

Medium-intensity statin therapy combined with taking a diuretic was found to increase the risk of hospitalization for acute kidney injury by 23% compared to non-users versus 6% for those not taking a diuretic during a median follow-up of 4.6 years according to a new study.

Medium-intensity statin therapy was defined as:

• Rosuvastatin less than 10 mg
• Atorvastatin less than 20 mg
• Simvastatin 20-40 mg
• Lovastatin 40 mg

Reference

Tonelli M, Lloyd AM, Bello AK, James MT, Klarenbach SW, McAlister FA, Manns BJ, Tsuyuki RT, and Hemmelgarn BR. Statin use and the risk of acute kidney injury in older adults. BMC Nephrol, 2019 Mar 25; 20(1): 103.

The paper is posted here:
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1280-7

Author’s Contact Info

Marcello Tonelli
Department of Medicine
University of Calgary
7th Floor, TRW Building
3280 Hospital Drive NW
Calgary, Alberta T2N 4Z6, Canada
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