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    Meridia (sibutramine) causes average weight loss of 9.8 lbs after one year

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, April 25, 2005 9:22 am Email this article
    Meridia (sibutramine) causes an average weight loss of 9.8 pounds more than placebo after one year according to a analysis by the RAND Corporation. Meridia weight loss after four to six months: 7.5 to 13.2 lbs

    The average weight loss in twelve studies lasting four to six months varied from 7.5 pounds to 13.2 pounds.

    Meridia weight loss after one year: 9.8 lbs

    The average weight loss in five studies lasting ten months to one year varied was 9.8 pounds.

    Meridia increased pulse 4 beats per minute

    Meridia (sibutramine) increased heart rate by an average of 4 beats per minute.

    Serious adverse effects: 1.5 per 1000 patients

    Serious adverse effects could occur in as many as 1.5 out of every 1,000 patients taking Meridia according to the paper.


    Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman L, Hilton L, Suttorp M, Solomon V, Shekelle P, Morton S. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005 Apr 5, 142(7):532-46.


    Southern California Evidence-Based Practice Center
    RAND Health Division
    1776 Main Street
    Santa Monica, CA 90401-3208
    Tel: 310-393-0411
    Fax: 310-393-4818

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