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    Meridia helps adolescents lose 17.2 pounds

    Posted by .(JavaScript must be enabled to view this email address)
    Saturday, September 20, 2003 4:00 pm Email this article
    Adolescents who were part of a family-based, behavioral weight control program lost twice as much weight when given Meridia (sibutramine) according to a recent study.

    Adolescents given Meridia (sibutramine) lost 17.2 pounds in six months compared to 7 pounds for those given a placebo. The weight loss represented 8.5 percent of body weight for the Meridia (sibutramine) group and 4 percent in the placebo group.

    The study included eighty-two obese adolescents with a body mass index (BMI) of 32 to 44 who were 13- to 17-years-old.

    During an additional six months adolescents who continued taking Meridia (sibutramine) gained 1.8 pounds whereas those who switched from taking the placebo to Meridia (sibutramine) lost an additional 2.9 pounds.

    The dose of Meridia (sibutramine) was reduced to 10 mg in sixteen subjects, to 5 mg in seven additional subjects, and discontinued in another ten subjects because of side effects—6 because of an increase in blood pressure or pulse rate, 2 because of a black and blue spot on the skin, one because of ventricular premature complexes, and one because of a skin rash.

    in 23 adolescents and discontinued in 10 because of increases in blood pressure, pulse rate or other symptoms.

    The authors concluded that Meridia (sibutramine) significantly increases weight loss in adolescents compared to behavioral therapy alone, but that Meridia (sibutramine) must be carefully monitored in both adults and adolescents to control increases in blood pressure and pulse rate.


    Berkowitz R, Wadden T, Tershakovec A, Cronquist J. Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial. JAMA. 2003 Apr 9, 289(14):1805-12.


    R. Berkowitz
    Department of Psychiatry
    Weight and Eating Disorders Program
    University of Pennsylvania School of Medicine
    Philadelphia 19104-3309
    .(JavaScript must be enabled to view this email address)

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