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  • Metformin plus a sulphonylurea increased the risk of death 96% over 10.7 years in Type 2 diabetics


    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, October 13, 2011 3:11 pm Email this article
    Adding the diabetes drug metformin (Glucophage) to Type 2 diabetics who were already taking a sulphonylurea DOUBLED the risk of diabetes-related death -- a 96% increase -- over 10.7 years compared with continued sulphonylurea alone according to a 1998 study.

    Metformin alone was the only diabetes drug to reduce the risk of death.

    Subjects

    Subjects: 753 Type 2 diabetics

    The study involved 753 Type 2 diabetics.

    “Of 4075 patients recruited to UKPDS in 15 centres, 1704 overweight (>120% ideal bodyweight) patients with newly diagnosed type 2 diabetes, mean age 53 years, had raised fasting plasma glucose (FPG; 6.1-15.0 mmol/L) without hyperglycaemic symptoms after 3 months’ initial diet,” according to the paper.

    “753 were included in a randomised controlled trial, median duration 10.7 years, of conventional policy, primarily with diet alone (n=411) versus intensive blood-glucose control policy with metformin, aiming for FPG below 6 mmol/L (n=342).”

    “A secondary analysis compared the
    342 patients allocated metformin with
    951 overweight patients allocated intensive blood-glucose control with
    chlorpropamide (n=265),
    glibenclamide (n=277), or
    insulin (n=409).”

    Sulphonylurea Drugs

    Sulphonylurea : List of

    Sulphonylurea Drugs include:

     

    Julian Whitaker, MD uses NO oral diabetes drugs

    Julian Whitaker, MD uses no oral diabetes drugs in Type 2 diabetics

    Julian Whitaker, MD from the Whitaker Wellness in Newport Beach, California uses NO oral diabetes drugs in Type 2 diabetics.

    Dr. Whitaker is the author of “Reversing Diabetes”.

    Reference

    Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (ukpds 34). Uk prospective diabetes study (ukpds) group. Lancet. 1998 Sep 12, 352(9131):854-65.

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