Mice given access to high-fat diet 24-hours/day weighed 38% more than mice given access 8-hours/day

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Thursday, November 22, 2012 12:00 pm Email this article

Mice given access to a high-fat diet 24-hours per day weighed 38% more than mice given access only 8-hours per day after 4.5 months even though both groups ate an equivalent number of calories.

Limiting eating to only 8-hours per day is called time-restricted feeding.

Time-restricted feeding of a high-fat diet causes metabolic changes which prevents obesity, Type 2 diabetes, fatty liver, inflammation and elevated insulin levels according to this study.

Diet

High-Fat Diet available 8-hours per day vs 24-hours per day

Groups of mice were given access to a high-fat (61% fat) diet either 8-hours per day or 24-hours per day.

Body Weight

Mice given access to High-Fat Diet 24-hours per day weighed 38% more than mice given access to food 8-hours per day

By the end of the 4.5 month study, the mice given access to a high-fat diet 24-hours per day weighed 38% more than the mice given access to the same high-fat diet only 8-hours per day.

The weight of the mice given access to a high-fat diet 24-hours per day was 47 grams versus 34 grams for the mice given access to the same high-fat diet only 8-hours per day.

Reference

Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, and Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab, 2012 Jun 6; 15(6): 848-860.

Author’s Contact Info

Satchidananda Panda
Salk Institute for Biological Studies
La Jolla, CA 92037, USA
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