Most common side effects of phentermine plus Topamax were paraesthesia, dry mouth, constipation

Posted by .(JavaScript must be enabled to view this email address)
Monday, April 25, 2011 10:31 am Email this article
The most common adverse events in people given phentermine plus Topamax (topiramate) were as follows.

The percentages shown are for those give 15 mg of phentermine plus 92 mg of Topamax (topiramate) versus those give 7.5 mg of phentermine plus 46 mg of Topamax (topiramate) versus placebo.

• Paraesthesia (tingling, pricking, or numbness of the skin) in 21% vs 14% vs 2%


• Dry Mouth in 21% vs 13% vs 2%


• Constipation in 17% vs 6% vs 5%


• Insomnia in 10% vs 7% vs 3%


• Dizziness in 10% vs 7% vs 3%


• Dysgeusia (altered taste) in 10% vs 7% vs 1%

Subjects

Subjects: 2487 overweight and obese patients

The study wad done at 93 centers in the US and involved 2487 overweight and obese patients who were 18- to 70-years-old, with an average age of 51.

Seventy percent (70%) of subjects were women.

• 994 were assigned to placebo
• 498 were given 7.5 mg of phentermine plus 46 mg of topiramate (Topamax)
• 995 were given 15 mg of phentermine plus 92 mg of topiramate (Topamax)

 

Body Weight

Average body weight: 226 lbs; BMI 36-37

The average body weight of the subjects was 226 pounds.

The average body mass index (BMI) was 36-37.

REFERENCE

Gadde K, Allison D, Ryan D, Peterson C, Troupin B, Schwiers M, Day W. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (conquer): A randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16, 377(9774):1341-52.

AUTHOR’S CONTACT INFORMATION

Dr Kishore M Gadde
Obesity Clinical Trials Programme
Box 3292
Duke University Medical Center
Durham, NC 27710, USA
.(JavaScript must be enabled to view this email address)

 

Other articles about Phentermine plus Topamax

Other articles about Phentermine plus Topamax

Other articles about Phentermine plus Topamax are posted here:

Robert Skversky, MD on Dr. Oz talking about Phentermine plus Topamax for weight loss, Part 1

Robert Skversky, MD on Dr. Oz talking about Phentermine plus Topamax for weight loss, Part 2

Robert Skversky, MD on Dr. Oz talking about Phentermine plus Topamax for weight loss, Part 3

Robert Skversky, MD on Dr. Oz talking about Phentermine plus Topamax for weight loss, Part 4

Robert Skversky, MD on Dr. Oz talking about Phentermine plus Topamax for weight loss, Part 5

Topamax (topiramate) caused average weight gain of 5.3 lbs in six months in migraine suffers

Woman loses 40 lbs on Topamax with Robert Skversky, MD

Woman loses 115 lbs on phentermine, Topamax and Lexapro with Robert Skversky, MD

How I use Topamax for weight loss by Robert Skversky, MD

Qnexa (phentermine plus Topamax) causes woman to lose 55 lbs, man 73 lbs

High-dose Qnexa: 15 mg Phentermine plus 92 mg Topamax causes weight loss of 10.4% vs 1.8% w/placebo

Mid-dose Qnexa: 7.5 mg Phentermine plus 46 mg Topamax causes weight loss of 8.4% vs 1.8% w/placebo

High-dose Qnexa: 15 mg Phentermine plus 92 mg Topamax causes weight loss of 11% vs 1.6% w/placebo

Low-dose Qnexa: 3.75 mg Phentermine plus 23 mg Topamax causes weight loss of 5.1% vs 1.6% w/placebo

Qnexa (Phentermine/Topamax) side effects dry mouth, tingling, constipation, altered taste, insomnia

Topamax (topiramate) used by 50% of weight loss doctors surveyed

Qnexa (Phentermine/Topamax) side effects dry mouth, tingling, constipation, altered taste, insomnia

Topamax and Zonegran can increase the risk of suicidal thoughts and behaviors according to the FDA

Topamax caused weight loss of 15.8 lbs in 59% of patients who gained weight on psychotropic drugs

43-year-old man loses 50 lbs in 4 months on phentermine plus Topamax (topiramate) - update

43-year-old man loses 44 lbs in 3 months on phentermine plus Topamax (topiramate)

Topamax caused psychosis in brother & sister; 75 mg twice a day in one, 25 mg twice a day the other

Type 2 Diabetics given Topamax lost 13.2 lbs vs 5.5 lbs for those given a placebo

 

Other articles about Phentermine plus Topamax Posted Later

Other articles about Phentermine plus Topamax posted after this article

Other articles posted after this article can be found here.

Articles on the same subject can be found here:

• Phentermine

• Qsymia (phentermine and topiramate) (formerly Qnexa)

• Topamax (topiramate)