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Most common side effects of phentermine plus Topamax were paraesthesia, dry mouth, constipation
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Monday, April 25, 2011 10:31 am Email this article
The most common adverse events in people given phentermine plus Topamax (topiramate) were as follows.
The percentages shown are for those give 15 mg of phentermine plus 92 mg of Topamax (topiramate) versus those give 7.5 mg of phentermine plus 46 mg of Topamax (topiramate) versus placebo.
- Paraesthesia (tingling, pricking, or numbness of the skin) in 21% vs 14% vs 2%
- Dry Mouth in 21% vs 13% vs 2%
- Constipation in 17% vs 6% vs 5%
- Insomnia in 10% vs 7% vs 3%
- Dizziness in 10% vs 7% vs 3%
- Dysgeusia (altered taste) in 10% vs 7% vs 1%
Subjects: 2487 overweight and obese patients
The study wad done at 93 centers in the US and involved 2487 overweight and obese patients who were 18- to 70-years-old, with an average age of 51.
Seventy percent (70%) of subjects were women.
- 994 were assigned to placebo
- 498 were given 7.5 mg of phentermine plus 46 mg of topiramate (Topamax)
- 995 were given 15 mg of phentermine plus 92 mg of topiramate (Topamax)
Body Weight
Average body weight: 226 lbs; BMI 36-37
The average body weight of the subjects was 226 pounds.
The average body mass index (BMI) was 36-37.
REFERENCE
Gadde K, Allison D, Ryan D, Peterson C, Troupin B, Schwiers M, Day W. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (conquer): A randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16, 377(9774):1341-52.
AUTHOR’S CONTACT INFORMATION
Dr Kishore M Gadde
Obesity Clinical Trials Programme
Box 3292
Duke University Medical Center
Durham, NC 27710, USA
.(JavaScript must be enabled to view this email address)
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