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  • Pamelor (nortriptyline) increases risk of diabetes 122%

    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, April 05, 2011 6:16 am Email this article
    The antidepressant nortriptyline (Aventyl HCl or Pamelor) increases the risk of diabetes 122% -- or 2.2-fold -- according to an analysis by researchers from Charité University Medical Center in Berlin, Germany.

    The dose was 30 mg per day or above that increased the risk.

    Note: This was not quite statistically significant, but it was so close I consider it irrelevant. To me, statistical significance is often misused to try and convince both doctors and the public that a link does not exist, but it is overwhelming likely that this increased risk of diabetes was due to the drug and not due to random chance.

    Those who had taken the drug for 2 years or more

    Those who had taken the drug for 2 years or more versus those who had not taken an antidepressant in the previous two years

    The study compared the risk of diabetes in people who had taken antidepressants for 2 years or more compared to those had not taken an antidepressants during the previous two years.



    Subjects: 165,958 patients

    The analysis looked at “165,958 patients with depression who received at least one new prescription for an antidepressant between January 1, 1990, and June 30, 2005”.



    Conclusion: Long-term use of antidepressants increases risk of diabetes

    “Long-term use of antidepressants in at least moderate daily doses was associated with an increased risk of diabetes. This association was observed for both tricyclic antidepressants and selective serotonin reuptake inhibitors,” the researchers concluded.


    Andersohn F, Schade R, Suissa S, Garbe E. Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry. 2009 May, 166(5):591-98.


    Frank Andersohn, MD
    Bremen Institute for Prevention Research and Social Medicine
    Epidemiology, and Health Economics
    Charité University Medical Center
    10098 Berlin, Germany
    .(JavaScript must be enabled to view this email address)

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