Obese have blunted thermogenesis in response to dietary fat

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Tuesday, August 10, 2010 7:00 am Email this article
Obese people's metabolism does not increase in response to dietary fat the same way that lean people do according to a study from researchers at Maastricht University in The Netherlands. Subjects

Subjects: 701 obese people, 113 lean people, 3 hours before and after high-fat meal

The study involved 701 obese people and 113 lean people who were analyzed for three-hours before and after eating a high-fat liquid meal.

 

Conclusions

Conclusion: Thermogenic response to dietary fat is blunted in the obese

“The 3-hour fat-induced thermogenic response is reduced in obesity,” the authors concluded.

Conclusion: Unsure if it is a cause or effect of obesity

They went on to state that they did not know whether this reduced thermogenesis could be part of the cause of obesity, or is caused by obesity.

“It remains to be determined whether this blunted thermogenic response is a contributory factor or an adaptive response to the obese state.”

REFERENCE

Blaak EE, Hul G, Verdich C, Stich V, Martinez J, Petersen M, Feskens E, Patel K, Oppert JM, Barbe P, Toubro S, Polak J, Anderson I, Astrup A, Macdonald I, Langin D, Sorensen T, Saris W. Impaired fat-induced thermogenesis in obese subjects: The nugenob study. Obesity (Silver Spring). 2007 Mar, 15(3):653-63.

AUTHOR’S CONTACT INFORMATION

Department of Human Biology
Nutrition Research Center
Maastricht University
PO Box 616
6200 MD Maastricht, The Netherlands
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• Metabolism

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