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    People with two genetic variants are on average 8.5 pounds heavier


    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, May 06, 2008 1:04 pm Email this article
    People with variants of the FTO gene and of the MC4R gene are, on average, 8.5 pounds heavier than those who do not have these genetic variants according to a new study of 90,000 people. People with a variant of the MC4R gene were, on average about 3.1 pounds heavier. Those with a variant of the FTO gene were, on average, about 6.2 pounds heavier. And those with variants of both genes were, on average, about 8.5 pounds heavier.

    "Dramatically, in a study of almost 6000 children, they found that the effects were almost double those seen in adults," the press release notes.

    "Between the ages of four and seven, this additional increase in weight was the result, almost exclusively, of gain of fat tissue, and not due to gain in muscle or other solid tissues." REFERENCE

    Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O’Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK, Lyon HN, Voight BF, Ridderstrale M, Groop L, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Ganz Vogel CI, Wallace C, Waterworth DM, Weedon MN, Willer CJ, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL, Wraight VL, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I. Common variants near mc4r are associated with fat mass, weight and risk of obesity. Nat Genet. 2008 May 4.

    AUTHOR’S CORRESPONDENCE

    Dr. Ruth Loos
    MRC Epidemiology Unit, Addenbrooke’s Hospital
    Cambridge CB2 0QQ, UK

    and

    Institute of Metabolic Science
    Addenbrooke’s Hospital
    Cambridge CB2 0QQ, UK

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