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  • Phentermine along with diet causes weight loss of 5-15% in two-thirds of patients

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, September 19, 2005 4:07 am Email this article
    Phentermine (Adipex, Fastin, Ionamin) in combination with a calorie-restricted diet causes a weight loss of 5 to 15 percent in sixty percent of patients according to review paper by Dr. Lisa L. Ioannides-Demos from Monash University in Melbourne, Australia. Phentermine every other month: 28.6 lbs lost

    One study found that women given phentermine every other months for nine months lost an average of 28.6 pounds which was 13.4 percent of their body weight.

    Phentermine every day: 26.8 lbs lost vs 10.6 lbs for placebo

    This compares to an average weight loss of 26.8 pounds or 13 percent of body weight for women who were given phentermine every day, and 10.6 pounds or 5.2 percent of body weight for women who were on the same diet and given a placebo.

    Most weight loss during first 6 months

    Most of the weight loss during the first six months, and much slower weight loss during the last three months.

    Subjects: 108 women, 30 mg of phentermine per day, 1000 calories per day

    The study started with 108 overweight women who were treated with 30 mg of phentermine per day and instructed to eat a diet containing approximately 1,000 calories.

    Completing the study: 53% on phentermine every day, 61% on phentermine intermittently, 69% on placebo

    How many women completed the study? Fifty-three percent taking phentermine every day, 61 percent taking phentermine every other month, and 69 percent given the placebo.

    This is a little bit surprising to me because my impression from other diet drug studies is that it is often people given the placebo who drop out because they have not lost much weight.

    Drop-outs due to side effects: 8% of phentermine patients vs 3% on placebo

    Eight percent of patients given phentermine dropped out due to side effects—mainly agitation, anxiety and insomnia—compared to 3 percent of patients given the placebo who dropped out for side effects.


    Ioannides-Demos LL, Proietto J, Mcneil JJ. Pharmacotherapy for obesity. Drugs. 2005, 65(10):1391-418.


    Dr. Lisa L. Ioannides-Demos
    National Health and Medical Research Council Centre for Clinical Research Excellence in Therapeutics
    Department of Epidemiology & Preventive Medicine
    Monash University
    Central & Eastern Clinical School
    The Alfred Hospital
    Commercial Road
    Melbourne, Victoria, Australia 3004
    .(JavaScript must be enabled to view this email address)

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