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Phentermine caused weight loss of 11.9 lbs in six weeks vs 7.9 lbs with placebo
Monday, April 21, 2008 1:16 pm Email this article
People given 30 mg of phentermine hydrochloride (phentermine Hcl) lost an average of 11.9 pounds in six weeks versus 7.9 pounds in patients given a placebo according to a 1975 study. Subjects
Subjects: 155 overweight people
That study involved 155 people who were at least 20% over their ideal weight.
Diet: 1000 calories per day
All subjects were put on a diet of 1000 calories per day.
First 2 Weeks
Everyone on placebo for first two weeks
For the first 2 weeks, all patients were given a placebo.
Weight Loss During First 2 Weeks While Everyone Taking Placebo
Weight loss during first 2 weeks while everyone on placebo: 4.2 lbs vs 4.5 lbs
During the first two weeks when all patients were on placebo, both groups lost a similar amount of weight (4.2 lbs for the phentermine group vs 4.5 lbs for the placebo group).
Next 6 Weeks
Next 6 weeks they were given 30 mg of phentermine Hcl or a placebo
For the next six weeks, patients were given either 30 mg of phentermine hydrochloride or a placebo in addition to their diet.
During these 6 weeks, while taking phentermine or placebo, the phentermine group lost 5 lbs more than the placebo group (8.3 pounds versus 3.3 pounds).
Weight Loss During Last 2 Weeks While Everyone Taking Placebo
Weight loss during last 2 weeks while everyone on placebo: weight gain of 0.4 lbs for phentermine group vs 0 lbs
For the last two weeks, all patients were again given a placebo.
During these last 2 weeks when both groups were again taking placebo, the phentermine group gained 0.4 pounds versus no weight change for the placebo group.
Total Weight Loss
Total weight loss: 11.9 lbs vs 7.9 lbs
At the end of the 2 month study, the phentermine group had lost 4 pounds more than the placebo group (11.9 lbs vs 7.9 lbs, representing 6.4 percent of their body weight versus 4 percent of their initial weight).
No significant side effects
Phentermine did not cause any significant side effects.
Wise PH. Clinical experience with a new dosage form of phentermine hydrochloride. Obesity Bariatric Medicine. 1975, 4:102-05.
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