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  • Proton pump inhibitors increase the risk of dementia by 44% according to German study

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    Monday, October 24, 2016 10:00 am Email this article

    Regular use of proton pump inhibitors (PPI’s) in the elderly were associated with a 44% greater risk of dementia according to an analysis from researchers at the German Center for Neurodegenerative Diseases in Bonn, Germany.


    The study analyzed 73,679 participants 75 years of age or older and free of dementia at baseline taking PPI’s and compared them to 70,729 who were not taking PPI’s.

    Supported by mouse models

    “This finding is supported by recent pharmacoepidemiological analyses on primary data and is in line with mouse models in which the use of PPIs increased the levels of beta-amyloid in the brains of mice,” the researchers noted.

    Increased levels of beta amyloid are found in Alzheimer’s patients.


    Most older people have too LITTLE stomach acid, NOT too much notes Jonathan Wright, MD

    Jonathan Wright, MD, a pioneer in natural medicine, notes that most people who are told that they have acid reflux have too little stomach acid, not too much, and what these people need are hydrochloric acid tablets, NOT acid blocking drugs such as proton pump inhibitors.

    See the articles about what Dr. Wright says about this posted here:

    Many people in 40’s and above get indigestion from LOW stomach acid notes Jonathan Wright, MD

    99% of the time indigestion, heartburn, bloating and gas is from LOW stomach acid, Jonathan Wright, MD

    NONE of his patients who were taking acid-blocking drugs had ever been tested, Jonathan Wright, MD

    People with low stomach acid often feel tired due to malnutrition, Jonathan Wright, MD

    About 5% of people with low stomach acid need stomach reconditioning, Jonathan Wright, MD

    Antacids and acid-blocking drugs cause malnutrition notes Jonathan Wright, MD

    People with low stomach acid or taking acid-blocking drugs are malnourished, Jonathan Wright, MD

    Stomach acid measured by gastric analysis by radio telemetry notes Jonathan Wright, MD


    Gomm W, von Holt K, Thome F, Broich K, Maier W, Fink A, Doblhammer G, and Haenisch B. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol, 2016 Apr; 73(4): 410-416.

    Author’s Contact Info

    German Center for Neurodegenerative Diseases
    Bonn, Germany

    Articles on the same subject can be found here:


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