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  • Simmondsin, a jojoba plant seed extract, reduces food intake and causes weight loss in rats

    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, February 08, 2006 4:42 am Email this article
    Simmondsin, a dietary supplement extracted from the seed of the jojoba plant (Simmondsia chinensis), reduced food intake and body weight in rats according to a study from Carol Boozer and A. J. Herron from Columbia University. DOSE

    Dose: 0.15% and 0.25% of food intake found effective and without negative effects

    Doses of 0.15 percent of food intake and 0.25 percent of food intake were effective and did not cause any apparent negative effects during the four month study.



    A dose of 0.5% of food intake had negative effect on red and white blood cells

    The highest dose tested, 0.5 percent of food intake, lowered red and white blood cells.



    Equivalent human dose would be 1500-2500 mg per day

    Humans eat roughly one kilogram of food per day, that is 1000 grams or 1,000,000 mg per day.

    Therefore, a dose of 0.15 percent of food intake would be the equivalent to 1.5 grams or 1500 mg per day for a human, and a dose of 0.25 percent of food intake would be 2.5 grams or 2500 mg per day.

    The highest dose tested, 0.5 percent of food intake, which caused adverse effects, would be the human equivalent of 5 grams or 5000 mg per day.

    Note: Doses do not always translate from rat to humans

    Note: Doses which are found effective in rodents do not always translate to humans.



    Conclusion: Future studies needed to test long-term effects

    “Future studies should determine long-term effects of lower doses on blood cell parameters,” Dr. Boozer concluded.


    Boozer CN, Herron AJ. Simmondsin for weight loss in rats. Int J Obes (Lond). 2006 Feb 7.


    Carol Boozer
    Department of Medicine
    Obesity Research Center
    St Luke’s-Roosevelt Hospital Center
    Columbia University College of Physicians and Surgeons
    New York, NY 10025, USA
    .(JavaScript must be enabled to view this email address)

    A. J. Herron
    Department of Medicine
    Institute of Human Nutrition
    Columbia University Medical Center
    New York, NY 10025, USA

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