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  • Splenda (sucralose) may increase irritable bowel, cardiovascular disease, obesity and cancer

    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, November 04, 2008 9:40 am Email this article
    Splenda (sucralose) reduces good bacteria in the gut as well as causes weight gain in rats both during use and after Splenda is stopped according to a study from Duke University.

    "Suppression of bacteria, alterations in microbial composition, and reduction in [short chain fatty acids] in the gut might have clinical significance for humans n the management of [ that is, it may increase the risk of ] imany medical conditions such as irritable bowel syndrome, inflammatory bowel disease, cardiovascular disease, obesity, and cancer, in which gut flora play an important role," according to the Duke researchers.

    No Splenda for me, thank you. Importance of Good Gut Bacteria

    Good bacteria very important for good health

    “Furthermore, recent studies using probiotics (e.g., lactobacilli and bifidobacteria) that modify bacterial balance for theraupeutic purposes further emphasize that even fairly small changes in gut flora may impact health and disease (Fukushima et al., 1998; Teitelbaum & Walker, 2002; Fooks & Gibson, 2002; Gill & Guarner, 2004),” the researchers noted.

    “The increase in pH is also noteworthy because changes in intestinal pH are known to modify the absorption of nutrients and drugs from the [gastrointestinal tract] (Dudeja et al., 2001; Asghar & Chandran, 2006).”


    Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, Mclendon R, Schiffman S. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008, 71(21):1415-29.


    Mohamed B. Abou-Donia
    Department of Pharmacology
    Duke University Medical Center
    Durham, North Carolina 27708, USA
    .(JavaScript must be enabled to view this email address)

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