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Time-restricted feeding (to 8-hours per day) results in normal glucose tolerance and insulin levels
Friday, November 23, 2012 9:10 am Email this article
Mice that were given access to a high-fat (61% fat) diet 24-hours per day showed glucose intolerance and elevated insulin levels (the equivalent of Type 2 diabetes), however mice that were given time-restricted access to the same high-fat diet only 8 hours per day (and fasted 16 hours per day) showed normal glucose tolerance and insulin levels even though both groups at an equivalent number of calories.
The mice given time-restricted access to the high-fat diet “did not display the hallmarks associated with glucose intolerance found in diet-induced obesity, instead showing glucose tolerance and insulin levels comparable to the control NA mice [mice who were given ad-lib access to a normal low-fat (13% fat) lab chow diet]” the authors of the paper note.
High-Fat Diet available 8-hours per day vs 24-hours per day
Groups of mice were given access to a high-fat (61% fat) diet either 8-hours per day or 24-hours per day.
Mice given access to High-Fat Diet 24-hours per day weighed 38% more than mice given access to food 8-hours per day
By the end of the 4.5 month study, the mice given access to a high-fat diet 24-hours per day weighed 38% more than the mice given access to the same high-fat diet only 8-hours per day.
The weight of the mice given access to a high-fat diet 24-hours per day was 47 grams versus 34 grams for the mice given access to the same high-fat diet only 8-hours per day.
Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, and Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab, 2012 Jun 6; 15(6): 848-860.
Author’s Contact Info
Salk Institute for Biological Studies
La Jolla, CA 92037, USA
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