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    Topamax causes 18-20 lbs weight loss in six months

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, July 12, 2004 12:18 pm Email this article
    A dose of 192 mg per day of Topamax (topiramate) caused as much weight loss as a dose twice that high -- 384 mg per day -- according to a study headed by George Bray. However, they also noted that lower dose -- 64 mg and 96 mg per day -- were better tolerated than higher doses, that is they caused fewer side effects, but still caused significant weight loss. Weight Loss

    For those who completed the study, weight loss at the end of six months was:

    Adverse Effects

    The most frequent adverse effects were

    Other adverse effects were

    Most adverse effects were dose-related, tended to occur early in treatment, and usually resolved spontaneously.


    Twenty-one percent of the people receiving Topamax withdrew from the study due to side effects compared to 11 percent in the placebo group.


    Topamax was started at 16 mg once per day.

    After one week, the dose was increased to 16 mg twice daily (32 mg per day).

    Each week thereafter, the dose was raised by 16 mg twice per day (an additional 32 mg per day) until subjects reached their target dose.


    People in this study were 18- to 75-years-old, and were either obese with a body mass index of 30 or more, or overweight, with a BMI of greater than 27 who also had either hypertension of elevated cholesterol or triglyceride levels.

    The study started with 385 people, approximately 75 people in each group.

    Approximately 85 percent of the subjects were female.

    The average weight was about 228 pounds.


    Bray G, Hollander P, Klein S, Kushner R, Levy B, Fitchet M, Perry B. A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res. 2003 Jun, 11(6):722-33.


    George Bray
    Pennington Biomedical Research Center
    Baton Rouge, Louisiana
    .(JavaScript must be enabled to view this email address)

    Articles on the same subject can be found here:


    On Jul 13, 2004 at 3:19 pm robert skversky wrote:

    . . . . .

    Larry, I emailed DR. Bray relating my experience with topamax. I mentioned the use of potassium to treat the paresthesias in addition to using provigil to treat the fatigue and possibly be of some help for the cognitive dysfunction. Since topamax can be used for partial complex seizures down to the age of 2, I also questioned whether he had plans to do a topamax study on overweight/obese adolescents. dr s

    On Jul 13, 2004 at 4:03 pm Larry Hobbs wrote:

    . . . . .

    Dr. Skversky,

    Thanks for the good information.

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