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  • Women lose 9%, Men 12% with Meridia (sibutramine)

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    Saturday, November 22, 2003 9:10 pm Email this article
    Meridia (sibutramine) causes dose-dependent weight loss according to a six month study in which 173 people were given varying doses of the drug (from 1 to 30 mg).

    Men and women were instructed to eat diets of 1500 and 1200 calories per day, respectively, and were advised to exercise 20-30 minutes each day. Weight loss increased from 3.1% to 9.2% in women as the dose increased from 1 mg to 30 mg. In men losses were 6.7% to 12.3% with the same doses. Patients still seemed to be losing weight at the end of the study.

    Side effect, which were more common at higher doses, included dry mouth, insomnia, constipation and decreased appetite. Meridia inhibits the reuptake of both noradrenaline and serotonin. This action is similar to that of the combination of fenfluramine and phentermine.


    Rosmond R, Lapidus L, Marin P, Bjorntorp. Mental Distress, obesity and body fat distribution in middle-aged men. Obesity Research, May 1996, 4(3):245-52.

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