QUICKLINKS AND VIEW OPITONS
Xenical and Alii (orlistat) may increase appetite and food consumption
Wednesday, October 08, 2008 11:34 am Email this article
Orlistat, which includes both the prescription drug Xenical and over-the--counter drug Alii, reduce secretion of appetite-reducing hormones in the gut, which could increase appetite according to a new study from researchers at St. Josef-Hospital at Ruhr-University in Bochum, Germany. Subjects
Subjects: 25 healthy people
The study involved 25 healthy people who given orlistat or a placebo followed by a solid-liquid test meal.
Findings: CCK 53% lower, PYY 40% lower, GLP-1 20% lower
After giving orlistat, blood levels of satiety hormones were as follows:
- CCK (cholecystokinin) 53% lower
- PYY (peptide YY) 40% lower
- GLP-1 (glucagon-like peptide-1) 40% lower
Appetite and Food Consumption
Increased Appetite and Food Consumption
“Satiety and fullness were lowered by Orlistat, whereas appetite and prospective food consumption increased,” the researchers noted.
Conclusion: Orlistat might increase appetite
“Orlistat alters gastric and gallbladder emptying and reduces the postprandial secretion of GLP-1, PYY and CCK. These changes in gastrointestinal hormone concentrations may raise appetite sensations and increase food consumption and should therefore be considered as potential side effects when applying lipase inhibitors for the treatment of morbid obesity,” the researcher conclude.
Ellrichmann M, Kapelle M, Ritter PR, Holst JJ, Herzig K-H, Schmidt WE, Schmitz F, Meier JJ. Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7–36)-amide-1, cholecystokinin, and peptide yy concentrations. Journal of Clinical Endocrinology & Metabolism. 2008 Sep-Oct, 93(10):3995-98.
AUTHOR’S CONTACT INFORMATION
Dr. Mark Ellrichmann
Department of Medicine I
44791 Bochum, Germany
Articles on the same subject can be found here:
Please feel free to share your comments about this article.
© Copyright 2003-2021 - Larry Hobbs - All Rights Reserved.