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  • Xenical causes weight loss of 4.7% in women with Polycystic Ovarian Syndrome (PCOS)

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    Tuesday, November 23, 2004 12:39 pm Email this article
    Xenical (orlistat) causes a weight loss of 4.7 percent in women with Polycystic Ovarian Syndrome compared to a weight loss of 1 percent for women given Glucophage (metformin). Subjects: Average of 27-years-old and BMI of 36.7

    On average the women were 27-years-old and had a body mass index (BMI) of 36.7.

    Both drugs reduced total testosterone

    Both drugs reduced total testosterone.

    Xenical (orlistat) reduced it from 115 ng/dl to 94 ng/dl, and metformin reduced it from 120 ng/dl to 97 ng/dl.


    Jayagopal V, Kilpatrick E, Holding S, Jennings P, Atkin S. Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome. J Clin Endocrinol Metab. 2004 Nov 9.


    V. Jayagopal
    Department of Medicine
    University of Hull
    Michael White Centre for Diabetes and Endocrinology
    Hull Royal Infirmary
    Hull, UK, HU3 2RW

    Department of Clinical Biochemistry and Immunology
    Hull Royal Infirmary
    Hull UK, HU3 2JZ

    Department of Medicine
    York Hospital
    York, UK, YO31 8HE

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