Belviq (lorcaserin), a weight loss drug, was associated with a 2-fold increased risk of moderate or greater mitral regurgitation after one-year of drug use according to a paper looking at side effects of the drug written by James DiNicolantonio, PharmD and others.
“Despite the fact that the lorcaserin package insert states that it does not cause a significant increase in FDA-defined valvulopathy, defined as mitral regurgitation greater than mild or aortic regurgitation greater than trace (pooled relative risk (RR) of the phase 3 echocardiographic data: 1.16; 95% CI 0.81 to 1.67), a look at the FDA Medical Review states that lorcaserin causes a significant increase in moderate or greater mitral regurgitation at week 52 (RR 1.95; 95% CI 1.05 to 3.59, p value not stated) and (RR 1.88; 95% CI 1.02 to 3.47, p=0.04) based on our forest plot) (figure 1),” the paper notes.
“These data were based on a meta-analysis of three randomised controlled trials testing lorcaserin 10 mg twice daily versus placebo.”
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