Coronary heart disease is a multifactorial disease that requires multifactorial intervention. This is the view of Dr. Dean Ornish and his group at the Preventive Medicine Research Institute, Sausalito, California, a view they share with many other doctors and researchers. Dr. Ornish and his group chose to intervene with a low-fat, low-cholesterol vegetarian diet, smoking cessation, stress-management training and moderate exercise. They selected 94 patients with a diagnosis of coronary artery disease according to a previous coronary angiogram. Fifty-three were randomly assigned to the experimental group and 43 to the control group, but when told about the design of the study only 28 and 20, respectively, agreed to participate.
A new angiogram was performed after one year, but one of the angiograms disappeared; in three patients the second angiogram could not be evaluated; one patient was not studied because of unpaid bills; one died during heavy exercise; and one dropped out because of alcohol misuse. Thus, only 22 patients in the experimental group and nineteen in the control group were available for analysis.
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