“Virtually all trials of psychotropic agents are flawed, not only because of the unblinding problem, but also because of their design,” writes Prof. Peter C. Gotzsche, MD in Chapter 3 titled Depression of his excellent book Deadly Psychiatry and Organised Denial.
“This was recognised decades ago, but drug trials and reviews have continued to pretend the problem doesn’t exist, likely because the psychiatrists choose to ignore everything that threatens the myths they have built up around their profession.
“There are many tricks.
“Some studies exclude patients who improve in the placebo lead-in period; some studies use active drugs in this period and exclude people who experience troublesome side effects; and some studies have both types of ‘cleansing,’ which was the case for one of the very few trials of fluoxetine in children that purported to have shown an effect.
“But even with this extremely biased design, the children fared no better on the drug than on placebo on self-rating scales or on ratings by their parents.
“The ‘effect’ was only seen on a secondary scale filled out by the psychiatrists who were paid by Lilly to run the trial!”
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