Orlistat, which is the active ingredient found in the weight loss drugs Xenical and Alli, inhibits a key enzyme, increases toxicity of the liver and kidneys, and reduces effectiveness of some anti-cancer drugs according to a study by Professor Bingfang Yan which was funded by the U.S. National Institutes of Health.
Yan notes that this inhibition occurs with a low level of the drug.
He also notes that “Since it has been available over–the-counter, there has been a drastic increase of toxicity among patients using the drug,” Yan said.
“It has been linked to severe liver failure, acute pancreatic failure and acute renal (kidney) failure.”
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